Protective Effect of Centranthus longiflorus subsp, longiflorus in Glutamate-Induced Neurotoxicity

Abstract

In the present study, neuroprotective effect of the aquoeus extract of Centranthus longiflorus subsp. Iongiflorus in glutamate induced toxicity in rat pups cerebellar granular cell culture was investigated. The extract at doses of 50 ?g.ml-1, 100 ?.g.ml-1 250 ?g.ml-1, 500 ?g.ml-1 and 1000 ?g.ml-1 was applied to culture flasks. At all doses the extract significantly blocked glutamate - induced neurotoxicity, with the most effective dose being 500 ?g.ml-1. As a result, Centranthus longiflorus subsp. longiflorus protected the neurons against glutamate toxicity.