Preventing Intraperitoneal Adhesions with Linezolid and Hyaluronic Acid/Carboxymethylcellulose: A Comparative Study in Cecal Abrasion Model

Abstract

Background We aimed to compare the effectiveness of linezolid in preventing intraperitoneal adhesions with hyaluronic acid + carboxymethylcellulose (Seprafilm). Methods Thirty rats were divided randomly into 3 groups: Group I (control), untreated; Group II (Seprafilm); and Group III (linezolid). All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, inflammation, and fibrosis were evaluated. Results The multiple comparisons between groups showed a statistically significant difference for adhesion. There were statistically significant differences between Group I and II and I and III, but no statistically significant difference between Group II and III. The multiple comparisons between the groups showed a statistically significant difference for inflammation and fibrosis. For inflammation and fibrosis, there was a statistically significant difference between Group I and II and I and III, but no statistically significant difference between Group II and III. Conclusion The efficiency of linezolid in reducing the formation of intraperitoneal adhesions was statistically significant compared with the control group. © 2014 Elsevier Inc. All rights reserved.