Publication:
Synthesis and Cytotoxic Activity of Some 1,2,4-Triazoline and 2,5-Disubstituted Derivatives

Simple item page
dc.authorscopusid6701878126
dc.authorscopusid35567972100
dc.authorscopusid55759722800
dc.authorscopusid7004106981
dc.authorscopusid6506416646
dc.authorscopusid7004090340
dc.authorscopusid7004090340
dc.authorwosidVázquez-López, Ezequiel M./A-1770-2008
dc.authorwosidVazquez-Lopez, Ezequiel M/A-1770-2008
dc.authorwosidKarakuş, Sevgi/Aai-4259-2020
dc.authorwosidÇoruh, Ufuk/Hjz-4626-2023
dc.contributor.authorKarakus, Sevgi
dc.contributor.authorCoruh, Ufuk
dc.contributor.authorBarlas-Durgun, Bilgehan
dc.contributor.authorVazquez-Lopez, Ezequiel M.
dc.contributor.authorOzbas-Turan, Suna
dc.contributor.authorAkbuga, Julide
dc.contributor.authorRollas, Sevim
dc.contributor.authorIDVazquez-Lopez, Ezequiel M/0000-0002-6012-0931
dc.contributor.authorIDÇoruh, Ufuk/0000-0002-8007-4629
dc.date.accessioned2020-06-21T09:27:26Z
dc.date.available2020-06-21T09:27:26Z
dc.date.issued2010
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Karakus, Sevgi; Barlas-Durgun, Bilgehan; Ozbas-Turan, Suna; Akbuga, Julide; Rollas, Sevim] Marmara Univ, Eczacilik Fak, Istanbul, Turkey; [Coruh, Ufuk] Ondokuz Mayis Univ, Egitim Fak, Samsun, Turkey; [Vazquez-Lopez, Ezequiel M.] Univ Vigo, Fac Ciencias Quim, Vigo, Galicia, Spainen_US
dc.descriptionVazquez-Lopez, Ezequiel M/0000-0002-6012-0931; Çoruh, Ufuk/0000-0002-8007-4629en_US
dc.description.abstractIn this search, a series of 5-[4-(4-fluorobenzoylamino) phenyl]-2-substitutedamino- 1,3,4-thiadiazole (2a-g) and 5-[4-(4-fluorobenzoylamino) phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione (3a-f) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, H-1-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany].en_US
dc.description.sponsorshipResearch Fund of Marmara University [SAG-65/1998]en_US
dc.description.sponsorshipThis work was supported by the Research Fund of Marmara University. Project Number: SAG-65/1998.en_US
dc.description.woscitationindexEmerging Sources Citation Index
dc.identifier.doi10.12991/201014454
dc.identifier.endpage90en_US
dc.identifier.issn1309-0801
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-79961138147
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.12991/201014454
dc.identifier.volume14en_US
dc.identifier.wosWOS:000216784600005
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Pharmacyen_US
dc.relation.journalMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxic Activityen_US
dc.subject1,2,4-Triazoline-3-Thioneen_US
dc.subject2,5-Disubstituted-1,3,4-Thiadiazoleen_US
dc.subjectMTT Assayen_US
dc.subjectX-Ray Crystallographyen_US
dc.titleSynthesis and Cytotoxic Activity of Some 1,2,4-Triazoline and 2,5-Disubstituted Derivativesen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu