Publication:
Inhibition of Human Carbonic Anhydrase Isozymes I, II and VI with a Series of Bisphenol, Methoxy and Bromophenol Compounds

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dc.authorscopusid6505649833
dc.authorscopusid22955598300
dc.authorscopusid23027537500
dc.authorscopusid23013520200
dc.authorscopusid6701789599
dc.authorscopusid6603339039
dc.contributor.authorBalaydin, H.T.
dc.contributor.authorDurdagi, S.
dc.contributor.authorEkinci, D.
dc.contributor.authorŞentürk, M.
dc.contributor.authorGöksu, S.
dc.contributor.authorMenzek, A.
dc.date.accessioned2020-06-21T14:18:35Z
dc.date.available2020-06-21T14:18:35Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Balaydin] Halis Türker, Faculty of Education, Artvin Coruh University, Artvin, Artvin, Turkey; [Durdagi] Serdar, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Şentürk] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Göksu] Süleyman, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Menzek] Abdullah Elah, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkeyen_US
dc.description.abstractCarbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and VI with a series of bisphenol and bromophenol derivatives was investigated. Molecular docking studies of a set of such inhibitors within CA I and II were also performed. KI values of the molecules 29 were in the range of 10.025892.109 μM for hCA I, 1.43759.107 μM for hCA II and 11.143919.182 μM for hCA VI, respectively. Reported inhibitory activities of molecules 29 will assist in better understanding of structure-activity relationship studies of CAI. © 2012 Informa UK, Ltd.en_US
dc.identifier.doi10.3109/14756366.2011.596836
dc.identifier.endpage475en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue4en_US
dc.identifier.pmid21815772
dc.identifier.scopus2-s2.0-84855413948
dc.identifier.scopusqualityQ1
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.596836
dc.identifier.volume27en_US
dc.identifier.wosWOS:000306524200001
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphenolen_US
dc.subjectBromophenolen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectHCA IIen_US
dc.subjectHCA VIen_US
dc.subjectMolecular Dockingen_US
dc.titleInhibition of Human Carbonic Anhydrase Isozymes I, II and VI with a Series of Bisphenol, Methoxy and Bromophenol Compoundsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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