Inhibition of Human Carbonic Anhydrase Isozymes I, II and VI with a Series of Bisphenol, Methoxy and Bromophenol Compounds

Abstract

Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and VI with a series of bisphenol and bromophenol derivatives was investigated. Molecular docking studies of a set of such inhibitors within CA I and II were also performed. KI values of the molecules 29 were in the range of 10.025892.109 μM for hCA I, 1.43759.107 μM for hCA II and 11.143919.182 μM for hCA VI, respectively. Reported inhibitory activities of molecules 29 will assist in better understanding of structure-activity relationship studies of CAI. © 2012 Informa UK, Ltd.