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Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

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dc.authorscopusid55391495500
dc.authorscopusid23097741000
dc.authorscopusid57225408957
dc.authorscopusid7005912992
dc.authorscopusid55318816300
dc.authorscopusid15733553800
dc.authorscopusid7004937377
dc.contributor.authorCengiz, N.
dc.contributor.authorKavak, S.
dc.contributor.authorGüzel, A.
dc.contributor.authorÖzbek, H.
dc.contributor.authorBektaş, H.
dc.contributor.authorHim, A.
dc.contributor.authorErdoǧan, E.
dc.date.accessioned2020-06-21T14:16:53Z
dc.date.available2020-06-21T14:16:53Z
dc.date.issued2013
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Cengiz] Nurettin, Department of Histology and Embryology, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Kavak] S., Department of Biophysics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Güzel] Ali, State Hospital, Bitlis, Tunceli, Turkey; [Özbek] Hanefí, Department of Drug and Pharmacy, T.C. Sağlık Bakanlığı,, Ankara, Turkey; [Bektaş] Hava, Department of Biophysics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Him] Aydin, Department of Biophysics, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Erdoǧan] Ender, Department of Histology and Embryology, Selçuk Üniversitesi, Selçuklu, Konya, Turkey; [Balahoroǧlu] Ragıp, Department of Biochemistry, Selçuk Üniversitesi, Selçuklu, Konya, Turkeyen_US
dc.description.abstractMore than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl<inf>4</inf>). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl<inf>4</inf>-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl<inf>4</inf>. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl<inf>4</inf> group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl<inf>4</inf> group. Sesame did not show a hepatoprotective effect in CCl<inf>4</inf>-induced liver toxicity. © 2012 Springer Science+Business Media, LLC.en_US
dc.identifier.doi10.1007/s00232-012-9494-7
dc.identifier.endpage6en_US
dc.identifier.issn0022-2631
dc.identifier.issn1432-1424
dc.identifier.issue1en_US
dc.identifier.pmid22915054
dc.identifier.scopus2-s2.0-84872383811
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s00232-012-9494-7
dc.identifier.volume246en_US
dc.identifier.wosWOS:000313202400001
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Membrane Biologyen_US
dc.relation.journalJournal of Membrane Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectALPen_US
dc.subjectALTen_US
dc.subjectASTen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectHistologyen_US
dc.subjectLiveren_US
dc.subjectRaten_US
dc.subjectSesameen_US
dc.subjectSesamum indicum L.en_US
dc.titleInvestigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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