Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

Abstract

More than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl<inf>4</inf>). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl<inf>4</inf>-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl<inf>4</inf>. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl<inf>4</inf> group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl<inf>4</inf> group. Sesame did not show a hepatoprotective effect in CCl<inf>4</inf>-induced liver toxicity. © 2012 Springer Science+Business Media, LLC.