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Preventive and Protective Effects of Turkish Propolis on H2O2-Induced DNA Damage in Foreskin Fibroblast Cell Lines

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dc.authorscopusid6506633542
dc.authorscopusid55674801800
dc.authorscopusid36904580100
dc.authorscopusid54419663000
dc.authorscopusid59846297900
dc.authorscopusid7004155081
dc.authorscopusid7004155081
dc.contributor.authorAliyazicioǧlu, Y.
dc.contributor.authorDemir, S.
dc.contributor.authorTuran, I.
dc.contributor.authorÇakiroğlu, T.
dc.contributor.authorAkalin, I.
dc.contributor.authorDeǧer, O.
dc.contributor.authorBedir, A.
dc.date.accessioned2020-06-21T14:29:31Z
dc.date.available2020-06-21T14:29:31Z
dc.date.issued2011
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Aliyazicioǧlu] Yüksel, Department of Medical Biochemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Demir] Selim, Department of Medical Biochemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Turan] İbrahim, School of Health, Gümüşhane Üniversitesi, Gumushane, Gumushane, Turkey; [Çakiroğlu] Tuğba Nigar, Department of Medical Biochemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Akalin] I., Department of Medical Biochemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Deǧer] Örhan, Department of Medical Biochemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Bedir] Abdulkerim, Department of Medical Biochemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThe aim of the present study was to evaluate the potential of Turkish propolis extracts if they prevent or protect foreskin fibroblast cells against hydrogen peroxide (H <inf>2</inf>O <inf>2</inf>)-induced oxidative DNA damage. Hydrogen peroxide (40 μM) was used as an inducer of oxidative DNA damage. The damage of DNA was evaluated by using the alkaline single cell gel electrophoresis (comet) assay. Turkish propolis extracts at concentrations of 25, 50, 75 and 100 μg/ml were prepared by ethanol. Anti-genotoxicity was assessed before, simultaneously, and after treatment of propolis extract (50 μg/ml) with H <inf>2</inf>O <inf>2</inf>. The results showed a significant decrease in H <inf>2</inf>O <inf>2</inf>-induced DNA damage in cultures treated with propolis extract. The antioxidant activity of phenolic components found in propolis may contribute to reduce the DNA damage induced by H <inf>2</inf>O <inf>2</inf>. Our findings confirmed the chemopreventive activity of propolis and showed that this effect may occur under different mechanisms. © 2011 Akademiai Kiado, Budapest.en_US
dc.identifier.doi10.1556/ABiol.62.2011.4.5
dc.identifier.endpage396en_US
dc.identifier.issn0236-5383
dc.identifier.issue4en_US
dc.identifier.pmid22119868
dc.identifier.scopus2-s2.0-82955225087
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1556/ABiol.62.2011.4.5
dc.identifier.volume62en_US
dc.identifier.wosWOS:000297798600005
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.journalActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Genotoxicityen_US
dc.subjectComet Assayen_US
dc.subjectForeskin Fibroblast Cellsen_US
dc.subjectPropolisen_US
dc.titlePreventive and Protective Effects of Turkish Propolis on H2O2-Induced DNA Damage in Foreskin Fibroblast Cell Linesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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