2-Aminofluorene Imine Compounds: Single Crystal Structure, Vanadium(III) Detection and Anticancer Activity

Abstract

The present paper reports the successful synthesis of three new 2-aminofluorene-appended Schiff's bases: FORMFLU, ANTFLU and BrFLU. The newly synthesized compounds were characterized by single crystal XRD, FTIR, NMR (1H and 13C) spectroscopy, TGA, and mass spectrometry. Crystallographic studies revealed that FORMFLU and BrFLU both have Monoclinic crystal system while ANTFLU has an orthorhombic lattice framework. All the compounds showed notable to commendable anticancer efficacy against Hela cervical cancer cell line. Computational molecular docking studies were conducted to elucidate the binding interactions mechanisms between ligands and proteins. The selective bonding of azomethine (-C--N-) of FORMFLU chemosensor by Vanadium(III) ions was carried out using UV-Vis. technique. FORMFLU chemosensor showed magnificent selectivity and sensitivity towards vanadium-III ions with a detection limit of 2.44 mu M. The results presented herein demonstrate the significant potential of FORMFLU chemosensors for the detection of Vanadium(III) ions in environmental, agricultural, and biological analysis systems.