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Rapid Direct Testing of Susceptibility of Mycobacterium tuberculosis to Isoniazid and Rifampin on Nutrient and Blood Agar in Resource-Starved Settings

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dc.authorscopusid36502982900
dc.authorscopusid23476981500
dc.authorscopusid7007135107
dc.authorscopusid7404932957
dc.contributor.authorSatti, L.
dc.contributor.authorIkram, A.
dc.contributor.authorÇoban, A.Y.
dc.contributor.authorMartin, A.
dc.date.accessioned2020-06-21T14:27:49Z
dc.date.available2020-06-21T14:27:49Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Satti] Muhammad Luqman, Department of Pathology, Combined Military Hospital, Multan, Multan, Pakistan; [Ikram] Aamer, Department of Pathology, National University of Medical Sciences, Rawalpindi, Punjab, Pakistan; [Çoban] Ahmet Yilmaz, Department of Medical Microbiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Martin] Anandi, EurolacTB, Antwerpen, Belgiumen_US
dc.description.abstractIn this study, we evaluated the performance of blood agar (by macroscopic growth) and nutrient agar (by a microcolony detection method) for drug susceptibility testing of Mycobacterium tuberculosis against rifampin (RIF) and isoniazid (INH), using 67 smear-positive sputum specimens. The direct proportion method on Lowenstein-Jensen (LJ) medium was used as the "gold standard." Compared with LJ medium, results for both media were in 100% agreement for RIF, while for INH the agreement levels for blood agar and nutrient agar were 98% and 95%, respectively. Within 2 weeks, 100% of specimens yielded results on blood agar, while 96.8% of specimens yielded results on nutrient agar. Our study showed that blood agar and nutrient agar can be used as alternative media for direct susceptibility testing of RIF and INH, especially in resource-poor settings. Copyright © 2012, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.doi10.1128/JCM.00013-12
dc.identifier.endpage1662en_US
dc.identifier.issn0095-1137
dc.identifier.issue5en_US
dc.identifier.pmid22357498
dc.identifier.scopus2-s2.0-84859949301
dc.identifier.scopusqualityQ1
dc.identifier.startpage1659en_US
dc.identifier.urihttps://doi.org/10.1128/JCM.00013-12
dc.identifier.urihttps://hdl.handle.net/20.500.12712/16558
dc.identifier.volume50en_US
dc.identifier.wosWOS:000302900500025
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherAmer Soc Microbiologyen_US
dc.relation.ispartofJournal of Clinical Microbiologyen_US
dc.relation.journalJournal of Clinical Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleRapid Direct Testing of Susceptibility of Mycobacterium tuberculosis to Isoniazid and Rifampin on Nutrient and Blood Agar in Resource-Starved Settingsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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