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Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors

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dc.authorscopusid8527557100
dc.authorscopusid23027537500
dc.authorscopusid6504284918
dc.authorscopusid23013520200
dc.authorscopusid6504118853
dc.contributor.authorGüney, M.
dc.contributor.authorEkinci, D.
dc.contributor.authorÇavdar, H.
dc.contributor.authorŞentürk, M.
dc.contributor.authorZilbeyaz, K.
dc.date.accessioned2020-06-21T13:40:10Z
dc.date.available2020-06-21T13:40:10Z
dc.date.issued2016
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Güney] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çavdar] Hüseyin, Education Faculty, Dumluplnar University, Kutahya, Turkey; [Şentürk] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Zilbeyaz] Kani, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkeyen_US
dc.descriptionAgri Ibrahim Cecen University; IC Foundationen_US
dc.description.abstractDiscovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. Some commercially available molecules (5-6) were also tested for comparison reasons. The novel UDCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low nanomolar concentrations with IC<inf>50</inf> values ranging from 2.68 to 166.6 nM as compared with well-known agents. © 2016 Author(s).en_US
dc.identifier.doi10.1063/1.4945930
dc.identifier.isbn9780735446496
dc.identifier.isbn9780735452794
dc.identifier.isbn9780735451889
dc.identifier.isbn9780735450301
dc.identifier.isbn9780735441088
dc.identifier.isbn9780735403598
dc.identifier.isbn9780735444577
dc.identifier.isbn9780735443594
dc.identifier.isbn9780735448001
dc.identifier.isbn9780735416437
dc.identifier.issn1551-7616
dc.identifier.scopus2-s2.0-84984548864
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1063/1.4945930
dc.identifier.volume1726en_US
dc.identifier.wosWOS:000376001000104
dc.language.isoenen_US
dc.publisherAmerican Institute of Physics Inc. subs@aip.orgen_US
dc.relation.ispartofAIP Conference Proceedingsen_US
dc.relation.ispartofseriesAIP Conference Proceedings
dc.relation.journalInternational Conference on Advances in Natural and Applied Sciences: Icanas 2016en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleBiological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitorsen_US
dc.typeConference Objecten_US
dspace.entity.typePublication

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