Plasma 25-OH Vitamin D3 Level in HIV-Infected Patients

Abstract

Vitamin D deficiency affects bone mineral density and immune function and thus may confer adverse outcomes in HIV infected patients. We aimed to determine plasma 25-OH Vit D-3 for evaluation of vitamin D status among HIV infected patients. Medical records were searched retrospectively and data were collected with ethical committee approval. One hundred twenty HIV infected patients who plasma 25-OH Vit D-3 level was determined by liquid chromatography tandem mass spectrophotometer enrolled into the study. Plasma 25-OH Vit D-3 levels of the patients ranged between 4.26 and 68.57 mu g/L (mean: 21.71 +/- 13.08 mu g/L). Normal plasma level (>30 mu g/L) was determined only in 26 (21.6%) patients. Female patients had lower plasma level (11.29 +/- 4.53 vs 24.19 +/- 13.24 mu g/L). There was also negative moderate correlation between age and plasma 25-OH Vit D-3 level (r:-0.42). Correlation between CD4 count and plasma 25-OH Vit D-3 level (r:-0.04) was not determined. In conclusion, majority of HIV infected patients (78.3%) had low level of plasma 25-OH Vit D-3. Therefore, it is important to determine vitamin D status of patients and give replacement therapy for its deficiency during care of HIV infected patients.