Serum Amyloid A May Be Associated with Hydatidiform Mole

Abstract

Hydatidiform mole (HM) is a gestational trophoblastic disease. Potential risk factors are advanced maternal age, reproductive factors, oral contraceptive use, history of gestational trophoblastic disease, oxidative stress, and other environmental factors. Serum amyloid A (SAA) protein has an important role in acute phase response but is also associated with pathologic fibril formation in chronic inflammation. The aim of the current study is to determine the relationship between maternal SAA levels in patients with both complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM), and to examine its potential role in the disease in pathogenesis. Fifty healthy pregnant women in the first trimester of pregnancy with completely normal pregnancy follow-up, and 50 patients who were diagnosed with HM, who were also in the first trimester of pregnancy included in the study. There was no difference between patients and the control group according to body mass index (BMI), gravidity, parity, number of living children, number of miscarriages, level of blood TSH, and hemoglobin level between the two groups. SAA levels in patients with HM were significantly higher than those in healthy controls. This may be an important underexplored pathway mediating the relationship between oxidative stress and abnormal placental proliferation © 2023 Ondokuz Mayis Universitesi. All rights reserved.