Investigation of Oxidative Stress Levels in Cats with Chronic Kidney Disease

Abstract

This study aimed to examine the oxidative stress levels and several biochemical parameters of cats diagnosed with CKD and evaluate their potential roles in disease monitoring and prognosis determination. Thirty cats diagnosed with CKD formed the CKD group, and 10 healthy cats formed the control group. For bio-chemical analyses, blood samples taken from the Vena cephalica antebrachii of cats were centrifuged. The serum was removed, and analyses were carried out. Among these analyses, biochemical parameters such as symmetric dimethylarginine (SDMA), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) and urea, creatinine, ALT, AST, and ALP levels were examined. According to the findings of the present study, while TAS levels were found to be low in cats diagnosed with CKD (P<0.05), TOS, OSI, MDA, and SDMA levels were found to be high (P<0.05). In addition, urea and creatinine levels and ALP and AST activities were greater in cats diagnosed with CKD than in healthy cats (P<0.05), whereas ALT activity did not change (P>0.05). These findings indicate that CKD is associated with increased oxidative stress in cats and that certain biochemical parameters can be used in the diagnosis of CKD. Therefore, oxidative stress is important in the pathophysiology of CKD, and the progression of this disease can be controlled by playing an important role in the diagnosis, monitoring, and treatment planning of kidney disease.