Chronic Granulomatous Disease With Recurrent Tuberculosis at Adolescent Child

Abstract

Chronic granulomatous disease (CGD) is an a primary immunodeficiency characterized by recurrent severe bacterial and fungal infections due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. Both extracellular and intracellular pathogens such as mycobacterium tuberculosis also cause important infectious diseases in these patients. The diagnosis is usually made in early childhood. However, partial enzyme deficiencies may delay the diagnosis. We presented a patient who first had recurrent tuberculosis infectious disease and later developed pulmonary aspergillosis and was diagnosed with CGD. Primary immune deficiency should be considered in the differential diagnosis in cases of recurrent tuberculosis infectious disease. Patients with primary immunodeficiency, such as CGD, may be contracted by recurrent tuberculous infectious disease before developing invasive pulmonary aspergillosis. In this way, at least in some patients, the infectious disease can be controlled more effectively and the recurrence of the infectious disease can be prevented.