Synthesis, Characterization and Biological Evaluation of a Novel Cu(II) Complex with the Mixed Ligands 2,6-Pyridinedicarboxylic Acid and 2-Aminopyridine

Abstract

A novel bridged binuclear Cu(II) complex with mixed ligands, di-μ-(2-aminopyridine(N,N′))-bis[(2,6-pyridinedicarboxylate)aqu acopper(II)] tetrahydrate, formulated as [Cu(μ-ap)(dipic)(H<inf>2</inf>O)]<inf>2</inf>·4H<inf>2</inf>O (1) (dipic = 2,6-pyridinedicarboxylate, ap = 2-aminopyridine), has been synthesized and characterized by elemental, spectral (IR and UV-Vis.), thermal analysis, magnetic measurements and single crystal X-ray diffraction analysis. The central Cu(II) ion resides on a centre of symmetry in a distorted square-pyramid coordination environment comprising of two N atoms, one from dipic and one from the ap ring, two carboxylate O atoms from dipic, and one O atom from water. Intermolecular N-H⋯O and O-H⋯O hydrogen bonds and π-π stacking interactions seem to be effective in the stabilization of the crystal structure. The free ligands and the complex were also evaluated for their antimicrobial and radical scavenging activities (DPPH = 1,1-diphenyl-2-picrylhydrazyl hydrate) using in vitro microdilution methods. Antimicrobial screening of the free ligands and their complex showed that the free ligands and the complex possess antifungal activity against Candida sp. © 2009 Elsevier Ltd. All rights reserved.