Evaluation of Clinical, Laboratory and Treatment Modalities of Pituitary Adenomas: Single Center Experience

Abstract

Pituitary adenomas are a group of disease with broad different clinical characteristics and complications. We aimed to present the data of patients being followed in a single center and discuss the pituitary adenomas based on the literature. Two hundred and twenty patients followed at Department of Endocrinology and Metabolism, Medical School of Ondokuz Mayis University, were included into study. Clinical characteristics, laboratory findings and treatment modalities were examined retrospectively. 59% of patients were female and 41% were male. Mean age during the diagnosis was 43.7 years. Pituitary macroadenomas were 62% of all adenomas and 73% of pituitary adenomas were functional. Among the functional adenomas, the most frequently seen types were prolactin-secreting adenoma and growth-hormone secreting adenoma. Treatment options were surgical treatment (67%), medical treatment (20%) and radiotherapy (7%). Post-operative complications were developed in 27 (13.2%) of patients. In patients with non-functional adenoma, the cure after surgery was detected as 19.6% and the remission after the surgery was detected as 8.9%. In this study, the characteristics of the pituitary adenomas were found similar to the literature in general. The early diagnosis of the disease has a significant importance in terms of treatment and the response to the treatment. © 2021 Ondokuz Mayis Universitesi. All rights reserved.