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Synthesis, Cytotoxicity and Apoptosis of Cyclotriphosphazene Compounds as Anti-Cancer Agents

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dc.authorscopusid10040320700
dc.authorscopusid24829334600
dc.authorscopusid55664812000
dc.authorscopusid35487408100
dc.authorscopusid34168278000
dc.authorscopusid8852671900
dc.authorscopusid8639397400
dc.contributor.authorYildirim, T.
dc.contributor.authorBilgin, K.
dc.contributor.authorÇiftçi, G.Y.
dc.contributor.authorTanriverdi Eçik, E.T.
dc.contributor.authorŞenkuytu, E.
dc.contributor.authorUludaǧ, Y.
dc.contributor.authorTomak, L.
dc.date.accessioned2020-06-21T14:27:44Z
dc.date.available2020-06-21T14:27:44Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Yildirim] Tuba, Department of Biology, Amasya Üniversitesi, Amasya, Turkey; [Bilgin] Kemal, Department of Medical Microbiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çiftçi] Gönül Yenilmez, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkey; [Tanriverdi Eçik] Esra, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkey; [Şenkuytu] Elif, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkey; [Uludaǧ] Yıldız Bozkurt, Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, Kavaklidere, Ankara, Turkey; [Tomak] Leman, Department of Biostatistics, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kılıç] Adem, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkeyen_US
dc.description.abstractIn the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, 1H and 31P NMR spectroscopy. At first, in vitro cytotoxic activity of cyclotriphosphazene compounds (1-14) against HT-29 (human colon adenocarcinoma), Hep2 (Human epidermoid larynx carcinoma), and Vero (African green monkey kidney) cell lines was investigated. Our study showed that most of these compounds stimulate apoptosis and they have cytotoxic effects for HT-29 and Hep2 cells. Additionally, these compounds (1-14) were investigated for their antibacterial activity against gram-positive (Staphylococcus aureus), gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and for their antifungal activity against Candida albicans, and were shown to be inactive. © 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejmech.2012.03.018
dc.identifier.endpage220en_US
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.pmid22483088
dc.identifier.scopus2-s2.0-84860328555
dc.identifier.scopusqualityQ1
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2012.03.018
dc.identifier.volume52en_US
dc.identifier.wosWOS:000304291600020
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.journalEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBiological Activityen_US
dc.subjectCyclotriphosphazeneen_US
dc.subjectCytotoxic Activityen_US
dc.subjectSpermine Derivativesen_US
dc.titleSynthesis, Cytotoxicity and Apoptosis of Cyclotriphosphazene Compounds as Anti-Cancer Agentsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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