The Relationship Between Matrix Metalloproteinase-1 Gene Promoter (-1607) Polymorphism and Aggressive Periodontitis

Abstract

Aim: The purpose of this study was to investigate the role of Matrix metalloproteinase-1 (MMP-1) -1607 1G/2G promoter polymorphism in aggressive periodontitis (AgP). Material and Methods: One hundred sixty-five systemically healthy volunteers comprising of 65 AgP and 100 periodontally healthy subjects were enrolled in this study. Full mouth radiological and clinical assessments of the periodontal tissues were performed. Genomic DNA was isolated from peripheral blood samples and amplified by PCR and analyzed by a restriction endonuclease. Results: There was statistically no significant difference in genotype (p=0.79) and allele frequencies (p=0.99) of MMP-1 -1607 polymorphism between AgP patients and periodontally healthy control group. Additionally, multiple logistic regression analysis was performed to adjust for possible confounding factors, such as age gender and smoking. Yet, the association still remained non-significant (p=0.57). The odds ratio (OR) 1G/1G vs. 1G/2G+2G/2G was 0.75(0.28-2,0; p=0.57) Discussion: Early identification of individuals at high-risk of developing periodontal diseases might be helpful for prevention and may contribute to the treatment of disease. MMP-1 is biologically a promising candidate gene that is involved in pathogenesis of AgP. However, our results showed that the MMP-1 (-1607) promoter polymorphism did not have a role in the susceptibility to AgP disease risk in Turkish population.