Serum Amyloid-A May Be an Early Marker in Diagnosis of Preterm Premature Rupture of Membrane and Chorioamnionitis

Abstract

Aim: To determine the efficiency of serum amyloid-A (SAA) in predicting preterm premature rupture of membrane (PPROM) andchorioamnionitis in risky cases.Study Design: The study consists of 20 women 26-37 weeks of pregnancy who had PPROM and 20 pregnant women without waterbreaks. Levels of SAA were determined in maternal venous and umbilical cord blood.Results: SAA values in cord blood and venous blood of mothers with PPROM were higher than in the control group (p<0,05). SAAvalues in the patients with clinical chorioamnionitis (n=9) were significantly higher (p<0,05) than both PPROM patients withoutchorioamnionitis (n=11) and the control group (n=20).Conclusion: In women at risk for PPROM in whom diagnosis cannot be established, blood SSA levels can be used as a marker. IncreasedSAA values in pregnant women with PPROM who were conservatively treated were considered a marker for chorioamnionitis.