Publication:
Premna integrifolia Linn: Phytochemical Profile and Evaluation of Antiproliferative Effects

Simple item page
dc.authorscopusid55098070600
dc.authorscopusid55838453200
dc.authorscopusid56032250100
dc.authorscopusid6701658113
dc.authorwosidAltun, Muhammed/B-2158-2013
dc.authorwosidDemirtas, Ibrahim/C-7274-2013
dc.contributor.authorRahman, Atiqur
dc.contributor.authorSiddiqui, Shah Alam
dc.contributor.authorAltun, Muhammed
dc.contributor.authorDemirtas, Ibrahim
dc.contributor.authorIDDemirtas, Ibrahim/0000-0001-8946-647X
dc.contributor.authorIDSiddiqui, Shah Alam/0000-0002-1707-6111
dc.contributor.authorIDRahman, Atiqur/0000-0003-4228-1149
dc.date.accessioned2025-12-11T01:29:33Z
dc.date.issued2023
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Rahman, Atiqur; Siddiqui, Shah Alam] Islamic Univ, Fac Engn & Technol, Dept Appl Chem & Chem Engn, Kushtia 7003, Bangladesh; [Altun, Muhammed] Cankiri Karatekin Univ, Fac Sci, Dept Chem, TR-18100 Cankiri, Turkiye; [Demirtas, Ibrahim] Igdir Univ, Fac Art & Sci, Dept Biochem, Igdir, Turkiye; [Demirtas, Ibrahim] Ondokuz Mayis Univ, Fac Pharm, Samsun, Turkiyeen_US
dc.descriptionDemirtas, Ibrahim/0000-0001-8946-647X; Siddiqui, Shah Alam/0000-0002-1707-6111; Rahman, Atiqur/0000-0003-4228-1149en_US
dc.description.abstractPremna integrifolia (PI) is a popular ethnomedicinal plant in Indian subcontinent and used for treating different types of ailments. Here, organic leaf extracts of PI have been studied for exploring phytochemical compositions and anti-proliferative properties of those extracts. The extracts have been investigated qualitatively and quantitatively by HPLC/TOF-MS, and fourteen phenolic compounds were identified including eupatorin, 4-hydroxybenzoic acid, diosmin, and apigenin as major compounds. The GC/MS study of hexane extract identified 9-octadecenoic acid, palmitic acid, phytol and stearic acid as main volatile organic compounds. xCELLigence (Real Time Cell Analyzer) has been used to study effects of different extracts on human cervical cancer cell lines (HeLa) at various concentrations. The chloroform and ethyl acetate extracts exhibited strong antiproliferative activities as a dose dependent manner. Our study explored PI as a source of biochemically active compounds having therapeutic potential as antiproliferative agent against cancer cells.en_US
dc.description.sponsorshipTUBITAK [2221]; Cankiri Karatekin University (Cankiri), Turkey [FF090316B03]en_US
dc.description.sponsorshipAtiqur Rahman is grateful to TUBITAK (Scientific and Technological Research Council of Turkey) 2221 for 7 months grant and to Cankiri Karatekin University (Cankiri), Turkey (Project No: FF090316B03).en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.doi10.1002/slct.202204854
dc.identifier.issn2365-6549
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85149525281
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202204854
dc.identifier.urihttps://hdl.handle.net/20.500.12712/44062
dc.identifier.volume8en_US
dc.identifier.wosWOS:000940792000001
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag GmbHen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCanceren_US
dc.subjectNatural Productsen_US
dc.subjectPhytochemical Characterizationen_US
dc.subjectTotal Phenolicsen_US
dc.titlePremna integrifolia Linn: Phytochemical Profile and Evaluation of Antiproliferative Effectsen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu