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The Use of Diclofenac Sodium in Urological Practice: A Structural and Neurochemical Based Review

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dc.authorscopusid56521486200
dc.authorscopusid55899813400
dc.authorscopusid57054834700
dc.authorscopusid6701482226
dc.contributor.authorUlubay, M.
dc.contributor.authorTufekci, K.K.
dc.contributor.authorKaplan, A.A.
dc.contributor.authorAtilla, M.K.
dc.date.accessioned2020-06-21T13:17:36Z
dc.date.available2020-06-21T13:17:36Z
dc.date.issued2018
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Ulubay] Mahmut, Urological Clinic, Gazi Hospital, Samsun, Samsun, Turkey; [Tufekci] Kıymet Kubra, Department of Histology and Embryology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kaplan] Arife Ahsen, Department of Histology and Embryology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Atilla] Mustafa Kemal, Urological Clinic, Samsun Training and Research Hospital, Samsun, Samsun, Turkeyen_US
dc.description.abstractDiclofenac sodium (DS) is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects. It is mainly found in the form of sodium salt. The mechanism of action of DS operates by way of cyclooxygenase (COX) inhibition. The physiological effect of this substance derives from a decrease in prostaglandin production. DS is a benzeneacetic acid derivative with anti-inflammatory properties. As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation. At the same time, this agent is also able to inhibit tumor angiogenesis, in which COX-2 is involved. DS is effective in overcoming pain and inflammation when it inhibits COX-2, but gastrointestinal side effects appear when it inhibits COX-1. In this review, we have focused on chemical structure and pharmacokinetic properties and renal effects of DS in light of current knowledge. Additionally, use of diclofenac nanoparticles were also discussed. © 2017en_US
dc.identifier.doi10.1016/j.jchemneu.2017.02.005
dc.identifier.endpage36en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.pmid28179185
dc.identifier.scopus2-s2.0-85013074877
dc.identifier.scopusqualityQ3
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2017.02.005
dc.identifier.volume87en_US
dc.identifier.wosWOS:000426028500005
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.journalJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclooxygenaseen_US
dc.subjectDiclofenac Sodiumen_US
dc.subjectNanoparticlesen_US
dc.subjectUrologyen_US
dc.titleThe Use of Diclofenac Sodium in Urological Practice: A Structural and Neurochemical Based Reviewen_US
dc.typeArticleen_US
dspace.entity.typePublication

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