Comparison of Multifocal Electroretinography Results with Two Different Electrodes in Patients Using Hydroxychloroquine: A Preliminary Study

Abstract

Purpose: To evaluate retinal electrophysiological responses with two different electrodes in patients who have been using HCQ at a dose of least 200 mg/day for more than five years and who are not known to have hydroxychloroquine (HCQ) retinal toxicity and to compare JET electrode data and H-K loop electrode data. Method: 20 eyes of 20 participants, 10 patients and 10 controls to whom HCQ treatment will be started, who were admitted consecutively to the clinic between October 2020 and March 2021 and who met the inclusion criteria were evaluated prospectively. Results: When the P1 wave amplitudes of both electrodes in the patient and control groups were compared, it was obtained lower in all waves in the patient group; Statistically significant difference was observed only in Ring 1 (p=0.029) in JET electrode, in ring 2 (p=0.019) and ring 3 (p=0.009) in H-K loop electrode. Discussion: The reason for the variation of the affected ring with respect to the electrode may be associated with the recorded localization of the electrode. In this respect, internal consistency of the electrodes draws attention. © © 2025 The author(s). This is an open-access article under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.