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Design, Stereoselective Synthesis, Computational Studies and Cholinesterase Inhibitory Activity of Novel Spiropyrrolidinoquinoxaline Tethered Indole Hybrid Heterocycle

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dc.authorscopusid8351597600
dc.authorscopusid6603003502
dc.authorscopusid36100384200
dc.authorscopusid57208244523
dc.authorscopusid7801614849
dc.authorscopusid40761083300
dc.authorscopusid57201886418
dc.authorwosidN, Dege/B-2545-2016
dc.authorwosidKansız, Sevgi/Aaq-1908-2020
dc.authorwosidKumar, Yeswanth/Kii-9701-2024
dc.authorwosidDege, Necmi/B-2545-2016
dc.authorwosidThota, Sai Manohar/Aaz-9546-2021
dc.authorwosidKumar, Raju Suresh/Abc-7605-2020
dc.authorwosidAlmansour, Abdulrahman/Aay-8328-2021
dc.contributor.authorArumugam, Natarajan
dc.contributor.authorAlmansour, Abdulrahman I.
dc.contributor.authorKumar, Raju Suresh
dc.contributor.authorYeswanthkumar, Santhakumar
dc.contributor.authorPadmanaban, Ramanathan
dc.contributor.authorArun, Yuvaraj
dc.contributor.authorVenketesh, S.
dc.contributor.authorIDN, Dege/0000-0003-0660-4721
dc.contributor.authorIDArun, Y/0000-0002-2258-9667
dc.contributor.authorIDSanthakumar, Yeswanth Kumar/0000-0003-3710-9205
dc.contributor.authorIDRamanathan, Padmanaban/0000-0003-1947-1868
dc.contributor.authorIDSivaramakrishnan, Venketesh/0000-0003-3094-5905
dc.contributor.authorIDThota, Sai Manohar/0000-0003-1710-5645
dc.contributor.authorIDSivaperumal, Sivaramakrishnan/0000-0002-1075-1014
dc.date.accessioned2025-12-11T01:40:23Z
dc.date.issued2021
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Arumugam, Natarajan; Almansour, Abdulrahman I.; Kumar, Raju Suresh] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Yeswanthkumar, Santhakumar; Padmanaban, Ramanathan] Pondicherry Univ, Sch Phys Chem & Appl Sci, Dept Chem, Kalapet 605014, Puducherry, India; [Arun, Yuvaraj] CSIR Cent Leather Res Inst, Organ & Bioorgan Chem Lab, Chennai 600020, Tamil Nadu, India; [Kansiz, Sevgi] Samsun Univ, Fac Engn, Dept Fundamental Sci, TR-55420 Samsun, Turkey; [Dege, Necmi] Ondokuz Mayis Univ, Fac Arts & Sci, Dept Phys, TR-55139 Samsun, Turkey; [Manohar, Thota Sai; Venketesh, S.] Sri Sathya Sai Inst Higher Learning, Dept Biosci, Prasanthinilayam 515134, AP, Indiaen_US
dc.descriptionN, Dege/0000-0003-0660-4721; Arun, Y/0000-0002-2258-9667; Santhakumar, Yeswanth Kumar/0000-0003-3710-9205; Ramanathan, Padmanaban/0000-0003-1947-1868; Sivaramakrishnan, Venketesh/0000-0003-3094-5905; Thota, Sai Manohar/0000-0003-1710-5645; Arumugam, Natarajan/0000-0001-9073-155X; Raju, Suresh Kumar/0000-0003-3754-4223; Sivaperumal, Sivaramakrishnan/0000-0002-1075-1014en_US
dc.description.abstractA facile eco-friendly approach for the regioand stereoselective synthesis of structurally intriguing novel spiropyrrolidinoquinoxaline tethered indole hybrid heterocycle has been accomplished via a cascade reaction sequence involving 1,3-dipolar cycloaddition as the key step. Structural elucidation of the synthesized spiroheterocycle was performed by NMR spectroscopy, mass spectrometric analysis and the stereochemistry of asymmetric carbons have been confirmed by single crystal X-ray diffraction analysis. The mechanistic rationalization for the formation of spiroheterocyclic hybrid was investigated through density functional theory (DFT) calculations. In addition, the synthesized spiroheterocyclic hybrid was tested for its cholinesterase inhibitory activity against ChEs and displayed good activity when compared to the standard drug galantamine. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP-2020/231]; Ondokuz Mayis University [PYO.FEN.1906.19.001]en_US
dc.description.sponsorshipThe project was supported by Researchers Supporting Project number (RSP-2020/231), King Saud University, Riyadh, Saudi Arabia. This study was supported by Ondokuz Mayis University under project No. PYO.FEN.1906.19.001.en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.doi10.1016/j.molstruc.2020.129165
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85090123827
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.129165
dc.identifier.urihttps://hdl.handle.net/20.500.12712/45328
dc.identifier.volume1225en_US
dc.identifier.wosWOS:000596475500001
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpiropyrrolidinesen_US
dc.subjectQuinoxalinoneen_US
dc.subject1,3-Dipolar Cycloaddition, DFT Calculationen_US
dc.subjectX-Ray Diffraction Analysisen_US
dc.subjectMolecular Docking Simulationen_US
dc.titleDesign, Stereoselective Synthesis, Computational Studies and Cholinesterase Inhibitory Activity of Novel Spiropyrrolidinoquinoxaline Tethered Indole Hybrid Heterocycleen_US
dc.typeArticleen_US
dspace.entity.typePublication

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