Synthesis, Crystal Structure, Spectral and Thermal Characterization, and Antimicrobial Activity of [Cu(hor)(aepy)(H2O)] · H2O (Aepy = 2-Aminoethylpyridine, Hor2- = Orotate)

Abstract

The copper(II) orotate complex with 2-aminoethylpyridine, [Cu(HOr)(aepy)(H<inf>2</inf>O)] · H<inf>2</inf>O, was synthesized and characterized by means of elemental and thermal analysis, magnetic susceptibility, IR and UV/vis spectroscopic, single crystal X-ray diffraction, and antimicrobial activity studies. The complex crystallizes in the triclinic system, space group F1̄, and the Cu(II) ion is five-coordinate with a distorted square-pyramidal coordination geometry. The aepy ligand and the orotate dianion behave as bidentate (N,N′ and N,O<inf>acid</inf>) chelating ligands. The crystal structure is stabilized by intermolecular O-H·O and N-H·O hydrogen bonds, and the orotate ligand exhibits a double hydrogenbonding functionality. The new compound was found active against some gram (+)/(-) bacteria and yeast Candida albicans ATCC 10231, but there was no activity on Aspergillus niger. © 2007 Verlag der Zeitschrift für Naturforschung.