A Severe 'Generalized Infantile Pustular Psoriasis' Case Healed with Low Dose Cyclosporine A

Abstract

Generalized pustular psoriasis is a rare disease which may be life threatening in children. Cyclosporine A is an immune suppressive agent that inhibits activated T cells via calcineurin inhibition. But the experience of its use in children is limited. Here, a 3-years old boy who diagnosed as pustular psoriasis by a skin biopsy but did not responded to acitretin treatment, then consulted to our clinic because of generalized erythrodermia and presumed sepsis due to loose of skin integrity was presented. In the severe forms of psoriasis that is classified as a Th1 disease, cyclosporine A can be the first choice drug. Copyright © 2011 by Türkiye Klinikleri.