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Increased Electrical and Metabolic Activity in the Dorsal Raphe Nucleus of Parkinsonian Rats

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dc.authorscopusid57206284748
dc.authorscopusid24436734500
dc.authorscopusid8301809900
dc.authorscopusid55922018200
dc.authorscopusid7003756799
dc.authorscopusid7006557045
dc.authorscopusid55769282400
dc.contributor.authorKaan Kaya, A.H.
dc.contributor.authorVlamings, R.
dc.contributor.authorTan, S.
dc.contributor.authorLim, L.W.
dc.contributor.authorMagill, P.J.
dc.contributor.authorSteinbusch, H.W.M.
dc.contributor.authorVisser-Vandewalle, V.
dc.date.accessioned2020-06-21T15:13:25Z
dc.date.available2020-06-21T15:13:25Z
dc.date.issued2008
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kaan Kaya] Hilmi Hilmî, Department of Neurosurgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey, Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands; [Vlamings] Rinske, Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlands; [Tan] Sonny Kian Hwie, Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlands; [Lim] Lee Wei, Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlands; [Magill] Peter J., University of Oxford, MRC Brain Network Dynamics Unit, Oxford, Oxfordshire, United Kingdom; [Steinbusch] Harry W.M., Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlands; [Visser-Vandewalle] Veerle E.R.M., Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlands; [Sharp] Trevor, University of Oxford Medical Sciences Division, Oxford, Oxfordshire, United Kingdom; [Temel] Yasin, Department of Neuroscience, Universiteit Maastricht, Maastricht, Limburg, Netherlands, Department of Neurosurgery, Maastricht Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands, European Graduate School of Neuroscience (EURON), Maastricht, Netherlandsen_US
dc.description.abstractSerotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. © 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2008.05.019
dc.identifier.endpage97en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid18565496
dc.identifier.scopus2-s2.0-46049108522
dc.identifier.scopusqualityQ3
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2008.05.019
dc.identifier.volume1221en_US
dc.identifier.wosWOS:000258254300011
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.ispartofBrain Researchen_US
dc.relation.journalBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDorsal Raphe Nucleusen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectSerotoninen_US
dc.subjectSubthalamic Nucleusen_US
dc.titleIncreased Electrical and Metabolic Activity in the Dorsal Raphe Nucleus of Parkinsonian Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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