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Expression of iNOS, COX-2 and VEGF in Canine Mammary Tumours and Non-Neoplastic Mammary Glands: Association With Clinicopathological Features and Tumour Grade

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dc.authorscopusid35975751700
dc.authorscopusid57189894144
dc.authorscopusid28767674800
dc.authorscopusid50561704700
dc.authorscopusid55695165700
dc.authorscopusid56050315600
dc.authorscopusid56050315600
dc.contributor.authorAnadol, E.
dc.contributor.authorYar-Saglam, A.S.
dc.contributor.authorGültiken, N.
dc.contributor.authorKarakas Alkan, K.
dc.contributor.authorAlçiǧir, E.
dc.contributor.authorAlkan, H.
dc.contributor.authorKanca, H.
dc.date.accessioned2020-06-21T13:18:31Z
dc.date.available2020-06-21T13:18:31Z
dc.date.issued2017
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Anadol] Elvan, Laboratory Animals Breeding and Experimental Researches Center, Gazi Üniversitesi, Ankara, Ankara, Turkey; [Yar-Saglam] Atiye Seda, Department of Medical Biology and Genetics, Gazi Üniversitesi, Ankara, Ankara, Turkey; [Gültiken] Nilgün, Department of Obstetrics and Gynecology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Karakas Alkan] Kubra, Department of Obstetrics and Gynecology, Ankara Üniversitesi, Ankara, Turkey; [Alçiǧir] Eray, Department of Pathology, Ankara Üniversitesi, Ankara, Turkey; [Alkan] Hasan, Department of Obstetrics and Gynecology, Selçuk Üniversitesi, Selçuklu, Konya, Turkey; [Kanca] Halit, Department of Obstetrics and Gynecology, Ankara Üniversitesi, Ankara, Turkeyen_US
dc.description.abstractThe aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent non-neoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours. © 2017 Akadémiai Kiadó, Budapest.en_US
dc.identifier.doi10.1556/004.2017.036
dc.identifier.endpage393en_US
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue3en_US
dc.identifier.pmid28956485
dc.identifier.scopus2-s2.0-85030548485
dc.identifier.scopusqualityQ2
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.1556/004.2017.036
dc.identifier.volume65en_US
dc.identifier.wosWOS:000411907900006
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rt. info@akkrt.huen_US
dc.relation.ispartofActa Veterinaria Hungaricaen_US
dc.relation.journalActa Veterinaria Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanine Mammary Tumoren_US
dc.subjectCOX-2en_US
dc.subjectGene Expressionen_US
dc.subjectiNOSen_US
dc.subjectVEGFen_US
dc.titleExpression of iNOS, COX-2 and VEGF in Canine Mammary Tumours and Non-Neoplastic Mammary Glands: Association With Clinicopathological Features and Tumour Gradeen_US
dc.typeArticleen_US
dspace.entity.typePublication

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