Publication:
Synthesis, Characterization and Anti-Inflammatory Activity of New 5-(3,4-Dichlorophenyl) Thio-1,3,4

Simple item page
dc.authorscopusid7003772860
dc.authorscopusid6701590971
dc.authorscopusid35561472800
dc.authorscopusid59454563700
dc.authorscopusid8382150200
dc.authorscopusid7004591192
dc.contributor.authorKoksal, Meric
dc.contributor.authorBilge, S. Sirri
dc.contributor.authorBozkurt, Ayhan
dc.contributor.authorSahin, Z. Sibel
dc.contributor.authorIsik, Samil
dc.contributor.authorErol, Dilek Demir
dc.date.accessioned2020-06-21T09:24:23Z
dc.date.available2020-06-21T09:24:23Z
dc.date.issued2008
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Köksal] Meriç, Department of Pharmaceutical Chemistry, Yeditepe University, Istanbul, Turkey, Department of Pharmaceutical Chemistry, Yeditepe University, Istanbul, Turkey; [Bilge] Süleyman Sirri, Department of Pharmacology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Bozkurt] Ayhan, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Şahin] Zarife Sibel, Department of Physics, Ondokuz Mayis University Faculty of Science and Arts, Samsun, Turkey; [Işík] Şamil, Department of Physics, Ondokuz Mayis University Faculty of Science and Arts, Samsun, Turkey; [Erol] Dılek Demir, Department of Pharmaceutical Chemistry, Yeditepe University, Istanbul, Turkeyen_US
dc.description.abstractSeveral 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. In addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug indometacin (CAS 53-86-1). © ECV Editio Cantor Verlag.en_US
dc.identifier.doi10.1055/s-0031-1296550
dc.identifier.endpage514en_US
dc.identifier.issn0004-4172
dc.identifier.issue10en_US
dc.identifier.pmid19025061
dc.identifier.scopus2-s2.0-55949113664
dc.identifier.startpage510en_US
dc.identifier.urihttps://doi.org/10.1055/s-0031-1296550
dc.identifier.volume58en_US
dc.language.isoenen_US
dc.publisherEditio Cantor Verlag GmbHen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.relation.journalArzneimittel-Forschung/Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,3,4-Oxadiazolesen_US
dc.subjectAntiinflammatory Activityen_US
dc.subjectS-Alkylationen_US
dc.subjectSynthesisen_US
dc.subjectX-Ray Crystallographyen_US
dc.titleSynthesis, Characterization and Anti-Inflammatory Activity of New 5-(3,4-Dichlorophenyl) Thio-1,3,4en_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu