Congenital Cerebellar Hypoplasia Associated with BVD-MD Virus Infection in a Naturally Infected Calf - A Case Report

Abstract

The objectives of the present study were to describe pathomorphological and immunohistochemical features of congenital cerebellar hypoplasia associated with natural BVD-MD virus infection in a Holstein-Friesian calf. The characteristic macroscopical lesion was cerebellar hypoplasia, almost completely absent, with hydrocephaly. Cerebellar changes were cortical destruction, destructive changes of granule and Purkinje cells and irregular cavity formation of the folia. The positive antibody reaction against the BVD-MD virus was observed in the CNS, but not in the eyes and peripheral nerves.