A Facile Ionic Liquid-Accelerated, Four-Component Cascade Reaction Protocol for the Regioselective Synthesis of Biologically Interesting Ferrocene Engrafted Spiropyrrolidine Hybrid Heterocycles

Abstract

Spiropyrrolidine engrafted ferrocene heterocycles were synthesized in excellent yields in a sustainable fashion employing an ionic liquid, 1-butyl-3-methylimidazoliumbromide accelerated one-pot multicomponent cycloaddition strategy. The in situ 1,3-dipole component derived from indenoquinoxalinone and L-phenylalanine that reacts with various substituted ferrocenyl chalcone in [bmim]Br affording spirocycloadduct. © 2020 The Author(s)