Publication:
Splenic Marginal Zone Lymphoma in Turkey: Association With Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor-A Multicenter Cohort Study

Simple item page
dc.authorscopusid57203951445
dc.authorscopusid55541727500
dc.authorscopusid8661414300
dc.authorscopusid7004442894
dc.authorscopusid56235570700
dc.authorscopusid57216677377
dc.authorscopusid6602557128
dc.contributor.authorOkay, M.
dc.contributor.authorAslan, T.
dc.contributor.authorÖzdemir, E.
dc.contributor.authorÜner, A.
dc.contributor.authorSaǧlam, A.
dc.contributor.authorGüngör, E.
dc.contributor.authorUysal, A.
dc.date.accessioned2020-06-21T12:18:50Z
dc.date.available2020-06-21T12:18:50Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Okay] Mufide, Department of Internal Medicine, Hacettepe Üniversitesi, Ankara, Turkey; [Aslan] Tuncay, Department of Internal Medicine, Hacettepe Üniversitesi, Ankara, Turkey; [Özdemir] Evren, Department of Medical Oncology, Ankara Numune Hospital, Ankara, Turkey; [Üner] Ayşegül Hasegeli, Hacettepe Üniversitesi, Ankara, Turkey; [Saǧlam] Arzu Emine, Hacettepe Üniversitesi, Ankara, Turkey; [Güngör] Elif, Department of Internal Medicine, Trakya Üniversitesi, Edirne, Edirne, Turkey; [Uysal] Ayse Oruç, Division of Hematology, University of Health Sciences, Istanbul, Turkey; [Aslan] Nevin Alayvaz, Department of Hematology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Yildizhan] Esra Taş, Department of Hematology, Erciyes Üniversitesi, Kayseri, Kayseri, Turkey; [Agit] Abdullah, Division of Hematology, Ankara Numune Education and Research Hospital, Ankara, Turkey; [Sinan Dal] Mehmet, Department of Hematology and BMT Unit, University of Health Sciences, Istanbul, Turkey; [Korkmaz] Serdal, Division of Hematology, Kayseri Training and Research Hospital, Kayseri, Kayseri, Turkey; [Namdaroǧlu] Sinem, University of Health Sciences, Istanbul, Turkey; [Şivgin] Serdar, Acibadem Kayseri Hospital, Kayseri, Kayseri, Turkey; [Çağlıyan] Gülsüm Akgün, Division of Hematology, T. C. Sağlık Bakanlığı, Denizli Devlet Hastanesi, Denizli, Turkey; [Demircioglu] Sinan, Department of Hematology, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Barişta] Ïbrahim, Department of Medical Oncology, Hacettepe Üniversitesi, Ankara, Turkey; [Özhamam] Esra Ucaryilmaz, Division of Pathology, Ankara Numune Education and Research Hospital, Ankara, Turkey; [Vural] Filiz, Department of Internal Medicine, Ege Üniversitesi, Izmir, Turkey; [Eser] Bülent, Department of Hematology, Erciyes Üniversitesi, Kayseri, Kayseri, Turkey; [Özet] Gülsüm Gulistan, Division of Hematology, Ankara Numune Education and Research Hospital, Ankara, Turkey; [Yıldırım] Rahşan, Department of Hematology, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Doǧu] Mehmet Hilmi, Clinic of Hematology, T. C. Sağlık Bakanlığı, Taksim Eğitim ve Araştirma Hastanesi, Istanbul, Turkey; [Berber] Ilhami, Division of Hematology, Malatya Training and Research Hospital, Malatya, Malatya, Turkey; [Erkurt] Mehmet Ali, Department of Internal Medicine, Inönü Üniversitesi, Malatya, Turkey; [Malkan] Umit Yavuz, Clinic of Hematology, University of Health Sciences, Istanbul, Turkey; [Altuntaş] Fevzi, Department of Hematology and BMT Unit, University of Health Sciences, Istanbul, Turkey, Department of Internal Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey; [Buyukasik] Yahya, Department of Internal Medicine, Hacettepe Üniversitesi, Ankara, Turkeyen_US
dc.description.abstractObjective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Materials and Methods: Data were gathered from participating centers from different regions of Turkey using IBM SPSS Statistics 23 for Windows. Hepatitis B virus surface antigen (HBsAg), anti-HBs antibody, anti-HB core antigen antibody (anti-HBcAg), HB viral load, anti-hepatitis C virus (HCV) antibody, HCV viral load results were analyzed. Results: One hundred and four patients were reported. Hepatitis C virus positivity was observed in only one patient. However, hepatitis B virus surface antigen (HBsAg) positivity was observed in 11.2% and HBsAg and/or anti-HB core antigen antibody (anti-HBcAg) positivities were seen in 34.2% of the patients. The median age was 60 years (range=35-87). Median follow-up duration was 21.2 months (range=00.2-212; 23.2 months for surviving patients). Median overall survival was not reached. Estimated 3-year and 10-year survival rates were 84.8% and 68.9%, respectively. Older age, no splenectomy during follow-up, platelet count of <90x103/µL, lower albumin, higher lactate dehydrogenase, higher β<inf>2</inf>-microglobulin, and HBsAg positivity were associated with increased risk of death. Only albumin remained significant in multivariable analysis. Conclusion: These results indicate that hepatitis B virus may be a possible risk factor for SMZL in our population. It may also be an indirect prognostic factor. © 2020 by Turkish Society of Hematology.en_US
dc.identifier.doi10.4274/tjh.galenos.2019.2019.0177
dc.identifier.endpage90en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue2en_US
dc.identifier.pmid31630512
dc.identifier.scopus2-s2.0-85084273046
dc.identifier.scopusqualityQ3
dc.identifier.startpage84en_US
dc.identifier.trdizinid365927
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2019.2019.0177
dc.identifier.urihttps://search.trdizin.gov.tr/en/yayin/detay/365927/splenic-marginal-zone-lymphoma-in-turkey-association-with-hepatitis-b-instead-of-hepatitis-c-virus-as-an-etiologic-and-possible-prognostic-factor-a-multicenter-cohort-study
dc.identifier.volume37en_US
dc.identifier.wosWOS:000531086600002
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherTurkish Society of Hematologyen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.journalTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis B Virusen_US
dc.subjectHepatitis C Virusen_US
dc.subjectLow-Grade Lymphomaen_US
dc.subjectRisk Factorsen_US
dc.titleSplenic Marginal Zone Lymphoma in Turkey: Association With Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor-A Multicenter Cohort Studyen_US
dc.title.alternativeTürkiye’de Splenik Marjinal Zon Lenfoma: Hepatit C Virüs Yerine Hepatit B Virüsünün Etiyolojik ve Olası Prognostik Faktör Oluşu-Çok Merkezli Kohort Çalışmasıen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu