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Synthesis and Antidiabetic Activity of 2,4-Thiazolidindione, Imidazolidinedione and 2-Thioxo Derivatives Bearing 6-Methyl Chromonyl Pharmacophore

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dc.authorscopusid55926099400
dc.authorscopusid8600292400
dc.authorscopusid55201197000
dc.authorscopusid7005611319
dc.authorscopusid7004022010
dc.authorscopusid6603464506
dc.contributor.authorCeylan-Ünlüsoy, M.C.
dc.contributor.authorKazak, C.
dc.contributor.authorBayro, O.
dc.contributor.authorVerspohl, E.J.
dc.contributor.authorErtan, R.
dc.contributor.authorBozdağ-Dündar, O.B.
dc.date.accessioned2020-06-21T14:04:16Z
dc.date.available2020-06-21T14:04:16Z
dc.date.issued2013
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Ceylan-Ünlüsoy] Meltem, Department of Pharmaceutical Chemistry, Ankara Üniversitesi, Ankara, Turkey; [Kazak] Canan, Department of Physics, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Bayro] Ornela, Department of Pharmacology, University of Münster, Munster, Nordrhein-Westfalen, Germany; [Verspohl] Eugene Joseph, Department of Pharmacology, University of Münster, Munster, Nordrhein-Westfalen, Germany; [Ertan] Rahmiye, Department of Pharmaceutical Chemistry, Ankara Üniversitesi, Ankara, Turkey; [Bozdağ-Dündar] Oya, Department of Pharmaceutical Chemistry, Ankara Üniversitesi, Ankara, Turkeyen_US
dc.description.abstractNumerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring. © 2013 Informa UK, Ltd.en_US
dc.identifier.doi10.3109/14756366.2012.723207
dc.identifier.endpage1210en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue6en_US
dc.identifier.pmid23057864
dc.identifier.scopus2-s2.0-84887462646
dc.identifier.scopusqualityQ1
dc.identifier.startpage1205en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2012.723207
dc.identifier.volume28en_US
dc.identifier.wosWOS:000326745800010
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2,4-Thiazolidinedionesen_US
dc.subject2-Thioxo-Imidazolidine-4-Onesen_US
dc.subjectAntidiabetic Drugsen_US
dc.subjectChromonyl-2,4-Thiazolidinedionesen_US
dc.subjectImidazolidine-2,4-Dionesen_US
dc.subjectInsulinotropic Activityen_US
dc.titleSynthesis and Antidiabetic Activity of 2,4-Thiazolidindione, Imidazolidinedione and 2-Thioxo Derivatives Bearing 6-Methyl Chromonyl Pharmacophoreen_US
dc.typeArticleen_US
dspace.entity.typePublication

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