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Antiviral Potential of Cistus L. Against Infectious Bronchitis Virus and SARS-CoV

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dc.authorscopusid59676904600
dc.authorscopusid57201072236
dc.authorscopusid57223380626
dc.authorscopusid59677460600
dc.authorscopusid57216735687
dc.authorscopusid7005079325
dc.authorscopusid7005079325
dc.contributor.authorBozoglan, F.
dc.contributor.authorErgüç, A.
dc.contributor.authorCoven, F.O.
dc.contributor.authorGungor Erkanli, G.
dc.contributor.authorAlp Onen, E.A.
dc.contributor.authorGören, A.C.
dc.contributor.authorNalbantsoy, A.
dc.date.accessioned2025-12-11T00:34:29Z
dc.date.issued2025
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Bozoglan] Feyruz, Department of Biotechnology, Ege Üniversitesi, Izmir, Turkey; [Ergüç] Ali, Department of Toxicology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Coven] Furkan Ozan, Department of Bioengineering, Ege Üniversitesi, Izmir, Turkey; [Gungor Erkanli] Gizem, Department of Bioengineering, Ege Üniversitesi, Izmir, Turkey; [Alp Onen] Engin Alp, Kocak Pharmaceuticals, Vaccine R&D Laboratory, Tekirdag, Turkey; [Gören] Ahmet Ceyhan, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkey; [Nalbantsoy] A. Ş., Department of Bioengineering, Ege University Faculty of Engineering, Bornova, Izmir, Turkeyen_US
dc.description.abstractCistus L. (Cistus) is distributed in Türkiye by 5 species including Cistus creticus L. (C. creticus), Cistus monspeliensis L. (C. monspeliensis), Cistus laurifolius L. (C. laurifolius), Cistus parviflorus L. (C. parviflorus) and Cistus salviifolius L. (C. salviifolius). In this study, antiviral activity of 5 Cistus extracts were investigated against Infectious bronchitis virus (IBV) using the in ovo antiviral activity assay, which measures both embryo viability and agglutination of chicken red blood cells. In further experiments, antiviral potential of C. creticus extract was also examined against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected Vero-E6 cells. In ovo antiviral activity assays displayed that C. parviflorus and C. monspeliensis extracts caused more antiviral activity against IBV-D274 strain than other extracts. Further asssays showed that C. creticus extract led to dose and time dependent antiviral activity against SARS-CoV-2. The results proposed that C. parviflorus and C. monspeliensis extracts might have a potential for the treatment of virus-mediated diseases. Increasing incubation time and concentration of C. creticus extract led to increase of antiviral activity against SARS-CoV-2, which means that C. creticus extract had potent antiviral activity. © 2025, Hacettepe University, Faculty of Pharmacy. All rights reserved.en_US
dc.identifier.doi10.52794/hujpharm.1525333
dc.identifier.endpage17en_US
dc.identifier.issn1300-0608
dc.identifier.issn2458-8806
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-86000511381
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.52794/hujpharm.1525333
dc.identifier.urihttps://hdl.handle.net/20.500.12712/37609
dc.identifier.volume45en_US
dc.language.isoenen_US
dc.publisherHacettepe University, Faculty of Pharmacyen_US
dc.relation.ispartofHacettepe University Journal of the Faculty of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiviralen_US
dc.subjectCistus L.en_US
dc.subjectIBVen_US
dc.subjectSARS-CoV-2en_US
dc.titleAntiviral Potential of Cistus L. Against Infectious Bronchitis Virus and SARS-CoVen_US
dc.typeArticleen_US
dspace.entity.typePublication

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