The Effect of Performance Score, Prognostic Nutritional Index, Serum Neutrophil-to Ratio, and Thrombocyte-to Ratio on Prognosis in Non-Small Cell Lung Cancer

Abstract

Objective: Systemic inflammatory markers and nutritional status of the patients can be helpful both in identifying high-risk cancer patients and in showing the prognosis of the disease. In this study we aimed to determine the effects of nutritional status and systemic inflammatory markers on prognosis in non-small cell lung cancer. Patients and Methods: Patients diagnosed with non-small cell lung cancer between 2015 and 2019 were analyzed retrospectively. The prognostic nutritional index (PNI), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio(NLR) were calculated and Eastern Cooperative Oncology Group performance status (ECOG PS), and the dates of death or last follow-up were recorded. Cox regression analysis and Kaplan-Meier curves were used to analyze the effects of parameters on survival. Results: In the study, a total of 219 patients were analyzed. 85.4% of the patients had died. At the third step Cox regression model, ECOG 3-4 (HR:2.18), PLR (HR:1.20) and PNI (HR:1.12) predicted the survival times. Patients with PNI>45 had a higher median survival (495 days) than patients with PNI<45 (314 days). Conclusion: In order to determine the prognosis of the patients at the time of diagnosis, it is recommended to use PNI and PLR values, which can he obtained through repeated tests and evaluated at low cost, together with performance scores.