The Investigation of the Efficacy of Nitric Oxide Against Mycobacterium Tuberculosis in Vitro

Abstract

In this study, the efficacy of NO against 15 Mycobacterium tuberculosis clinical isolates was examined. DETA-NO was used as NO donor. Minimum inhibitor concentrations (MIC) for NO detected with microdilution method by using Middlebrook 7H9 broth with OADC (oleic acid, albumin, dextroz, catalase). In this assay detected MIC values for clinical isolates were found in a range of 0.015-0.125 mg/ml. According to our results NO was efficient to M. tuberculosis.