A Comparison of Propofol With Ketofol for Sedation Quality and Side Effects in Patients Undergoing Colonoscopy

Abstract

Colonoscopy is an endoscopic method and ıt is better to perform this procedure under sedoanalgesia in order to eliminate patients' anxiety, the colic-like pain and discomfort that occur during the procedure. The aim of this study was to compare the effects of propofol and propofol+ketamine (ketofol) on sedation and side effects in patients undergoing colonoscopy. 50 patients with ASA I-II that are between the ages of 18-65. The patients in the propofol group and Ketofol group were given 0.1mL/kg of drug and/or combination of drugs. The vital parameters, injection pain, spontaneous time of opening eyes, the time of Modified Aldrete Score (MAS) ≥ 9 and the amount of medication used during the procedure and in the recovery, room were recorded. There was no significant difference between the two groups during the procedure and in the recovery room (p<0.05). It was shown that the ketamine reduces the amount of propofol by 50% and propofol induced injection pain. Ketofol had no positive effects on hemodynamic and respiratory parameters. We assert that the ratio of combinations will vary depending on the necessary sedation level and analgesic need of the procedure to be performed and depending on the frequency of the administration of additional doses. Although ketofol is being used in different procedures and different age groups in the recent years, there is still need for studies conducted with different drug dosages of this combination. © 2021 Ondokuz Mayis Universitesi. All rights reserved.