Does Late and Early Onset Depression Differ in Terms of Inflammation

Abstract

Objective: To compare neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) values as inflammation markers in patients with early-and late-onset geriatric depression. Method: Patients aged 60 and over who were hospitalized due to depressive disorder between 01.01.2012 and 01.01.2020 were included in this retrospective record review study. Only patients with unipolar depression were included. Results: No difference was found in terms of NLR, PLR or MLR was found between early-and late-onset depression. However, NLR and PLR values were higher in the early-and late-onset depression groups than in the control group. Lymphocyte and monocyte counts were higher in the control group compared to the early-and late-onset depression groups. Conclusion: NLR and PLR may be regarded as markers reflecting inflammation in geriatric depression patients rather than as markers that can differentiate geriatric depression patients in terms of disease onset time.