Publication:
Carbonic Anhydrase Inhibitory Properties of Some Uracil Derivatives

Simple item page
dc.authorscopusid57190938318
dc.authorscopusid23013520200
dc.authorscopusid7102904152
dc.authorscopusid23027537500
dc.contributor.authorTürkoǧlu, E.
dc.contributor.authorŞentürk, M.
dc.contributor.authorSupuran, C.T.
dc.contributor.authorEkinci, D.
dc.date.accessioned2020-06-21T13:26:51Z
dc.date.available2020-06-21T13:26:51Z
dc.date.issued2017
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Türkoǧlu] Emir Alper, Department of Pharmaceutical Technology, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Şentürk] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Supuran] Claudiu T., Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Florence, FI, Italy; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractInhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The K<inf>I</inf> values of the compounds 4–12 are in the range of 0.085–428 µM for hCA I and of 0.1715–645 µM against hCA II, respectively. It is concluded from the kinetic investigations, all compounds used in the study act as competitive inhibitors with substrate, 4-NPA. Uracil derivatives are emerging agents for the inhibiton of carbonic anhydrase which could be used in biomedicine. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/14756366.2016.1235043
dc.identifier.endpage77en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue1en_US
dc.identifier.pmid28097897
dc.identifier.scopus2-s2.0-85015599725
dc.identifier.scopusqualityQ1
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1080/14756366.2016.1235043
dc.identifier.volume32en_US
dc.identifier.wosWOS:000392591100053
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd healthcare.enquiries@informa.comen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectHydroxylen_US
dc.subjectInhibitoren_US
dc.subjectUracil Derivativesen_US
dc.titleCarbonic Anhydrase Inhibitory Properties of Some Uracil Derivativesen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu