A Fetus With t(5;8) (q33,2; q22,2) Karyotype

Abstract

We discussed a fetus with t(5; 8)(q33,2; q22,2) balanced reciprocal translocation whose mother referred to the laboratory due to advanced maternal age. Was After assessing the case's pedigree, the preparations obtained from case and relatives using peripheric blood culture method were evaluated with GTG banding. Cytogenetic analysis of fetus, showed a balanced reciprocal translocation 46, XY, t(5; 8)(q33,2; q22,2). Cytogenetic analyses of father, mother and two siblings revealed that the karyotypes of them were normal. We suggested that this balanced reciprocal translocation may be the result of an error of DNA repair mechanisms that may be associated with advanced maternal age. We discussed cytogenetic features of the fetus in the guide of literature.