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The Hematological Side Effects of Alpha-Interferon Therapy in Children with Chronic Viral Hepatitis

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dc.authorscopusid6505769164
dc.authorscopusid7004669257
dc.authorscopusid36943456600
dc.authorscopusid6602111071
dc.authorscopusid6701356032
dc.contributor.authorKanber, Y.
dc.contributor.authorKalaycı, A.G.
dc.contributor.authorYildirim, H.
dc.contributor.authorDaǧdemir, A.
dc.contributor.authorAlbayrak, D.
dc.date.accessioned2025-12-11T02:09:56Z
dc.date.issued2002
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kanber] Yilmaz, Tip Fakultesi, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kalaycı] Ayhan Gazi, Tip Fakultesi, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Yildirim] Hasan, Tip Fakultesi, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Daǧdemir] Ayhan, Tip Fakultesi, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Albayrak] Davut, Tip Fakultesi, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractInterferon is standard therapy for chronic viral hepatitis in children. Although it is usually tolerated, there are a lot of side effects of interferon, as tile bone marrow suppression is one of them. The aim of this study was to evaluate the hematological side effects of alpha-interferon in 40 consecutive children (32 males: age range, 4 to 15 years) affected by chronic hepatitis B treated with 5-10 MU/m2 for 6 months. The lowest peripheral blood cells counts were observed between the first and second month of therapy. Dosage of interferon was directly correlated with bone marrow suppression rate. The interferon dosage was reduced in none of them, because of leucopenia or thrombocytopenia. As a result: in therapy of chronic viral hepatitis B with interferon, hematological side effect is not a handicap for continuation of the therapy in children.en_US
dc.identifier.endpage173en_US
dc.identifier.issn1300-2996
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0036439752
dc.identifier.scopusqualityN/A
dc.identifier.startpage168en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12712/47698
dc.identifier.volume19en_US
dc.identifier.wosqualityN/A
dc.language.isotren_US
dc.relation.ispartofOndokuz Mayis Universitesi Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectInterferonen_US
dc.subjectSide Effectsen_US
dc.titleThe Hematological Side Effects of Alpha-Interferon Therapy in Children with Chronic Viral Hepatitisen_US
dc.title.alternativeKronik B Hepatitli Çocuklarda İnterferon Tedavisinin Hematolojik Yan Etkilerien_US
dc.typeArticleen_US
dspace.entity.typePublication

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