Publication:
Changes in IGF-I, IGFBP-3 and Ghrelin Levels after Adenotonsillectomy in Children with Sleep Disordered Breathing

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dc.contributor.authorGuemuessoy, Murat
dc.contributor.authorAtmaca, Sinan
dc.contributor.authorBilgici, Birsen
dc.contributor.authorUenal, Recep
dc.contributor.authorIDGUMUSSOY, MURAT/0000-0003-3258-7312
dc.date.accessioned2020-06-21T14:53:50Z
dc.date.available2020-06-21T14:53:50Z
dc.date.issued2009
dc.departmentOMÜen_US
dc.department-temp[Guemuessoy, Murat -- Atmaca, Sinan -- Uenal, Recep] Ondokuz Mayis Univ, Sch Med, Dept Otolaryngol, Samsun, Turkey -- [Bilgici, Birsen] Ondokuz Mayis Univ, Sch Med, Dept Biochem, Samsun, Turkey --en_US
dc.description.abstractObjective: The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB). Methods: Forty children (mean age 4.85 +/- 2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A. Results: Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p < 0.001). Serum ghrelin levels showed a significant decrease after T&A (p < 0.001). Conclusion: Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2009.08.025
dc.identifier.endpage1656en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue12en_US
dc.identifier.pmid19765833
dc.identifier.startpage1653en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2009.08.025
dc.identifier.urihttps://hdl.handle.net/20.500.12712/18329
dc.identifier.volume73en_US
dc.identifier.wosWOS:000272855900009
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIGF-Ien_US
dc.subjectIGFBP-3en_US
dc.subjectGhrelinen_US
dc.subjectAdenotonsillar Hypertrophyen_US
dc.subjectSleep Disordered Breathingen_US
dc.subjectAdenotonsillectomyen_US
dc.titleChanges in IGF-I, IGFBP-3 and Ghrelin Levels after Adenotonsillectomy in Children with Sleep Disordered Breathingen_US
dc.typeArticleen_US
dspace.entity.typePublication

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