Effects of Lidocaine and Prednisolone on Endoscopic Rigid Laryngoscopy

Abstract

OBJECTIVE/HYPOTHESIS: The aim of this study is to compare the effects of lidocaine and methylprednisolone on postoperative respiratory complications caused by short-term laryngeal surgery by way of rigid laryngoscope under general anesthesia. The effects of these drugs on recovery from anesthesia are also compared. STUDY DESIGN: One hundred American Society of Anesthesiologists physical status I to II patients over 20 years of age admitted for laryngeal mass, nodule, or polyp were included in this prospective, placebo-controlled, randomized, and double-blinded study. METHODS: Patients were randomly allocated to four groups; methylprednisolone 3 mg.kg (group 1), 0.9% saline physiologic 5 mL (group 2), lidocaine 1.5 mg.kg (group 3) intravenously, seven puffs of lidocaine aerosol 10% to oropharyngolaryngeal structures topically (group 4) sprayed. Anesthesia recovery time was calculated. Respiratory system was evaluated using a scoring table during early postoperative period. RESULTS: Ninety-two cases were suitable for analysis. Recovery time was longer in group 1 (9.8 3± 3.79 minutes) than in groups 3 and 4 (7.22 ± 2.38, 7.50 ± 2.30 minutes, respectively) (P < .05). Postoperative respiratory complications were lower in groups 3 and 4 than group 2 (P < .05). CONCLUSIONS: Lidocaine intravenous or topical administration was effective in reducing postoperative respiratory complications after short-term laryngeal surgery by way of rigid laryngoscope. Methylprednisolone prolonged recovery time from anesthesia. © 2006 The American Laryngological, Rhinological and Otological Society, Inc.