Evaluation of the Effectiveness of Using Two Different Probiotics in Helicobacter Eradication Treatment

Abstract

Introduction: We aimed to evaluate the effects of the addition of probiotics containing Lactobacillus acidophilus\r+ Bifidobacterium animalis Subsp lactis to the classic triple treatment protocol (lansoprozole +\ramoxycillin + clarithromycin) on the success of Helicobacter pylori eradication and antibiotic side effects.\rMaterials and Methods: Standard therapy (lansoprozole + amoxycillin + clarithromycin), and probiotics containing\rin addition to standard therapy were determined. Patients in both groups were treated for 14 days.\rThe prebiotic, containing two different strains, was in capsule form and used twice a day. We demonstrated\rthe helicobacter eradication status by looking at the helicobacter antigen from the stool. Statistical analyzes\rbetween the two groups were made using the pearson Chi-square test. P<0.05 was accepted as the\rsignificance level.\rResults: The rate of discontinuing treatment due to side effects was 15.3% in group 1, this rate was 4.5% in\rgroup 2. When double probiotics were added to the treatment, it was observed that there was a decrease\rof 11.2% in serious side effects (p<0.001). After the completion of the treatments. It was observed that\rhelicobacter eradication was achieved in 152 out of 222 patients (68%) in group 1 and in 214 (89%) of 240\rpatients in group 2. When double probiotics were added to the treatment, it was observed that the success\rof eradication increased by 21% (p<0.001).\rConclusion: Combined use of probiotic increases helicobacter eradication in addition to reducing the side\reffects of antibiotics due to H. pylori.