Association between Sport Performance and Alpha-Actinin Gene R577X Polymorphism

Abstract

Physical performance has been associated with many gene variants including the alpha-actinin-3gene (ACTN3) R577X polymorphism. The purpose of the present study is to investigate whether there is anassociation between sport performance of Turkish elite athletes and alpha-actinin-3 gene R577X polymorphism.A total of 300 individuals (150 elite athletes and 150 sedentary individuals) participated in the study voluntarily.A 291-bp long region spanning the R577X polymorphic site of the alpha-actinin-3 gene was amplified and testedwith polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. Thestatistical analyses were done by using SPSS 15.0 package program. Although, no significant difference was foundbetween the distributions of the three genotypes of elite athletes and sedentary individuals, the frequency of XXgenotype in sedentary individuals was lower than that of the elite athletes (p>0.05). The RX and XX frequencieswere significantly different (P<0.05) between the two groups. To the best of the researchers’ knowledge, there areno reports that examined the ACTN3 polymorphism in the Athletes who live in Black sea region of Turkey. © Kamla-Raj 2015.