Publication:
Melatonin Protects Retinal Tissue Damage in Streptozotocin-Induced Aged Rats

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dc.authorscopusid57769455000
dc.authorscopusid57196117192
dc.authorscopusid58010346400
dc.authorscopusid6602822147
dc.authorscopusid6701691429
dc.authorwosidBaltaci, Bugra/Aba-6885-2020
dc.authorwosidAkgun Unal, Nilufer/Hji-8285-2023
dc.authorwosidBaltaci, Abdulkerim/Aba-7831-2020
dc.contributor.authorAtacak, Adem
dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorAkgun-Unal, Nilufer
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorIDBaltaci, Saltuk Bugra/0000-0002-9752-7508
dc.date.accessioned2025-12-11T00:52:44Z
dc.date.issued2023
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Atacak, Adem; Baltaci, Saltuk Bugra; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim] Selcuk Univ, Med Fac, Dept Physiol, Konya, Turkiye; [Akgun-Unal, Nilufer] Univ Ondokuz Mayis, Fac Med, Dept Biophys, Samsun, Turkiyeen_US
dc.descriptionBaltaci, Saltuk Bugra/0000-0002-9752-7508;en_US
dc.description.abstractObjectives: The aim of this study was to investigate how melatonin administration affects retinal oxidative damage and retinal SIRT1 gene activation in diabetic elderly female rat model. Methods: 16-months-old female rats were used in the study. A total of 24 rats were divided into 4 groups in equal numbers: Group 1. Control, Group 2. Control + Melatonin, Group 3. Diabetes, Group 4. Diabetes + Melatonin. In group 3 and 4 rats, diabetes was induced by intraperitoneal (IP) injection of streptozotocin. Groups 2 and 4 were given ip melatonin for 4 weeks. SIRT-1 gene expression was determined by PCR method and GSH and MDA levels by ELISA in retinal tissue samples taken from animals sacrificed under general anesthesia. Results: In our study, the highest retinal SIRT1 expression values were obtained in the diabetes + melatonin (G4) group. The retinal SIRT1 expression values of the diabetes group (G3) were lower than group 4 and higher than the general control (G1) and control + melatonin (G2) groups. Again in our study, the highest retinal MDA values were obtained in the diabetes group (G3). The highest retinal GSH values were obtained in the Diabetes + melatonin group (G4). Conclusion: The results of our study showed that melatonin supplementation has a protective effect on retinal tissue in a diabetic elderly female rat model. This protective effect of melatonin supplementation occurs by increasing both retinal antioxidant activity and retinal SIRT1 gene expression.en_US
dc.description.sponsorshipScientific Research Projects Coor-dinatorship of Selcuk University; [19202021]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coor-dinatorship of Selcuk University (SUBAPK; project no. 19202021) .en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.doi10.1016/j.archger.2023.105035
dc.identifier.issn0167-4943
dc.identifier.issn1872-6976
dc.identifier.pmid37075585
dc.identifier.scopus2-s2.0-85152524452
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.archger.2023.105035
dc.identifier.urihttps://hdl.handle.net/20.500.12712/39916
dc.identifier.volume112en_US
dc.identifier.wosWOS:001053396600001
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofArchives of Gerontology and Geriatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectRetinal Tissueen_US
dc.subjectSIRT1en_US
dc.subjectOxidative Stressen_US
dc.subjectMelatoninen_US
dc.titleMelatonin Protects Retinal Tissue Damage in Streptozotocin-Induced Aged Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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