Trans-rac-[1-Oxo-2-Phenethyl-3-(2-Thienyl)-1,2,3,4-Tetrahydroisoquinolin-4-yl]methyl 4-Methylbenzenesulfonate

Abstract

The title compound, C<inf>29</inf>H<inf>27</inf>NO<inf>4</inf>S <inf>2</inf>, was synthesized by reaction of trans-rac-4-(hydroxy-meth-yl)-2- phenethyl-3-(thio-phen-2-yl)-3,4-dihydro-isoquinolin-1(2H)-one and 4-methyl-benzene-1-sulfonyl chloride in the presence of Et<inf>3</inf>N in CH<inf>2</inf>C<inf>l2</inf>. The relative orientations of the benzene ring (A) of the 3,4-dihydro-isoquinolinone ring system, the thio-phene ring (B), the benzene ring (C) of the methyl-benzene group and the phenyl ring (D) result in the following dihedral angles: A/B = 80.91 (16), A/C = 22.79 (18), A/D = 9.9 (2), B/C = 80.73 (19), B/D = 88.9 (2) and C/D = 29.9 (2)°. The crystal structure is stabilized by weak inter-molecular C - H⋯O hydrogen bonds and C - H⋯π inter-actions.