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Synthesis, Characterization and Anti-Inflammatory Activity of New 5-(3,4-Dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiaxoles

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dc.authorwosidBozkurt, Ayhan/A-5825-2012
dc.authorwosidSahin, Sibel/Kgl-0953-2024
dc.authorwosidBilge, S.Sırrı/C-1508-2014
dc.contributor.authorKoksal, Meric
dc.contributor.authorBilge, S. Sirri
dc.contributor.authorBozkurt, Ayhan
dc.contributor.authorSahin, Z. Sibel
dc.contributor.authorIsik, Samil
dc.contributor.authorErol, Dilek Demir
dc.contributor.authorIDKoksal, Meric/0000-0001-7662-9364
dc.contributor.authorIDSahin, Zarife Sibel/0000-0003-2745-7871
dc.date.accessioned2025-12-11T01:21:14Z
dc.date.issued2008
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Koksal, Meric; Erol, Dilek Demir] Yeditepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34755 Istanbul, Turkey; [Bilge, S. Sirri] Ondokuz Mayis Univ, Fac Med, Dept Pharmacol, Samsun, Turkey; [Bozkurt, Ayhan] Ondokuz Mayis Univ, Fac Med, Dept Physiol, Samsun, Turkey; [Sahin, Z. Sibel; Isik, Samil] Ondokuz Mayis Univ, Fac Arts & Sci, Dept Phys, Samsun, Turkeyen_US
dc.descriptionKoksal, Meric/0000-0001-7662-9364; Sahin, Zarife Sibel/0000-0003-2745-7871;en_US
dc.description.abstractSeveral 5-(3,4-dichlorophenvi)-2(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. in addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug indometacin WAS 53-86-1).en_US
dc.description.woscitationindexScience Citation Index Expanded - Index Chemicus
dc.identifier.endpage514en_US
dc.identifier.issn0004-4172
dc.identifier.issue10en_US
dc.identifier.pmid19025061
dc.identifier.startpage510en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12712/43130
dc.identifier.volume58en_US
dc.identifier.wosWOS:000261271400006
dc.language.isoenen_US
dc.publisherECV-editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,3,4-Oxadiazolesen_US
dc.subjectAnti-Inflammatory Activityen_US
dc.subjectS-Alkylationen_US
dc.subjectSynthesisen_US
dc.subjectX-Ray Crystallographyen_US
dc.titleSynthesis, Characterization and Anti-Inflammatory Activity of New 5-(3,4-Dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiaxolesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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