Publication:
Pyridazinone Substituted Benzenesulfonamides as Potent Carbonic Anhydrase Inhibitors

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dc.authorscopusid55829459000
dc.authorscopusid23027537500
dc.authorscopusid23013520200
dc.authorscopusid10144474900
dc.authorscopusid36768812400
dc.authorscopusid55249795800
dc.authorscopusid56265194900
dc.contributor.authorYaseen, R.
dc.contributor.authorEkinci, D.
dc.contributor.authorŞentürk, M.
dc.contributor.authorHameed, A.Dh.
dc.contributor.authorOvais, S.
dc.contributor.authorRathore, P.
dc.contributor.authorSamim, M.
dc.date.accessioned2020-06-21T13:34:26Z
dc.date.available2020-06-21T13:34:26Z
dc.date.issued2016
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Yaseen] Raed, Department of Chemistry, Jamia Hamdard, New Delhi, India; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Şentürk] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Hameed] Alhamzah D., Department of Chemistry, Jamia Hamdard, New Delhi, India; [Ovais] Syed Mohammad, Department of Chemistry, Jamia Hamdard, New Delhi, India; [Rathore] Pooja, Department of Chemistry, Jamia Hamdard, New Delhi, India; [Samim] Mohammed, Department of Chemistry, Jamia Hamdard, New Delhi, India; [Javed] Kalim, Department of Chemistry, Jamia Hamdard, New Delhi, India; [Supuran] Claudiu T., Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Florence, FI, Italyen_US
dc.description.abstractA series of sulfonamide derivatives (2a-l) incorporating substituted pyridazinone moieties were investigated for the inhibition of two human cytosolic carbonic anhydrase isoforms, hCA I and hCA II. All these compounds, together with the clinically used sulfonamide acetazolamide were investigated as inhibitors of the physiologically relevant isozymes I and II. These sulfonamides showed very strong inhibition against all these isoforms with K<inf>I</inf>'s in the range of 0.98-8.5 nM which makes such molecules possible to be used as leads for discovery of novel effective CA inhibitors targeting other isoforms with medicinal chemistry applications. © 2016 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bmcl.2015.12.016
dc.identifier.endpage1341en_US
dc.identifier.issn1464-3405
dc.identifier.issue4en_US
dc.identifier.pmid26804228
dc.identifier.scopus2-s2.0-84958110321
dc.identifier.scopusqualityQ3
dc.identifier.startpage1337en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2015.12.016
dc.identifier.urihttps://hdl.handle.net/20.500.12712/13496
dc.identifier.volume26en_US
dc.identifier.wosWOS:000369377700049
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.journalBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnzyme Inhibitorsen_US
dc.subjectHuman Carbonic Anhydraseen_US
dc.subjectSulfonamidesen_US
dc.titlePyridazinone Substituted Benzenesulfonamides as Potent Carbonic Anhydrase Inhibitorsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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