Vitamin B12 Deficiency as a Treatable Cause of Severe Brain Atrophy

Abstract

We report here two infants with vitamin B12 deficiency who presented with delay in motor and mental development. Neuroimaging studies in our cases revealed diffuse severe cerebral atrophy. Follow-up MRI after vitamin B12 treatment showed significant regression of the brain atrophy. Early diagnosis and treatment in infantile vitamin B12 deficiency are important to prevent the irreversible neurological damage.